Ademetionine Adonate (PREMIUM SAMe)
Composition:
1 tablet contains: main ingredient: 500 mg S-adenosyl-L-methionine disulphate 
p-toluenesulphonate;
additional ingredients: film coating: shellac, acetic acid esters, mono- and diglycerides of fatty acids, polyvinylpyrrolidone; anti-caking agent: silicon dioxide, magnesium salts of fatty acids; filler: microcrystalline cellulose, magnesium hydroxide, sodium carboxymethylcellulose.
Does not contain milk, eggs, fish, shellfish, nuts, peanuts, wheat, soy, sesame or gluten. 
Adonat® Premium SAMe is produced naturally by biotransformation of Saccharomyces cerevisiae yeast cultures.
Recommendations for use:
Consume as a dietary supplement to the main diet as an additional source of the amino acid ademetionine to normalise the functional state of the hepatobiliary system in intrahepatic cholestasis, which can be observed in: fatty liver disease, chronic hepatitis, toxic liver damage, and cirrhosis of the liver.
Ademetionine is necessary for the synthesis of neurotransmitters such as serotonin, noradrenaline, and dopamine, a decrease in the levels of which may be associated with the development of mood disorders and depression. Exogenous intake of ademetionine can restore endogenous ademetionine levels and increase the synthesis of these neurotransmitters, which may be beneficial in depressive disorders.
Ademetionine also helps maintain the functional state of the cartilage matrix by synthesising and integrating sulphur-containing amino acids into proteoglycans, which are necessary for the construction of cartilage tissue (transsulphuration process). By ensuring sufficient levels of the antioxidant reduced glutathione, ademetionine also reduces oxidative stress in the joints, which may be beneficial for maintaining joint function.

Method of consumption and recommended daily intake:
As recommended by a doctor, take 1-2 tablets per day on an empty stomach with sufficient liquid. The tablets should not be chewed or crushed, but taken whole. The product is suitable for vegetarians. The duration of use is determined by the doctor individually.
Precautions for use:
Do not use: in case of individual intolerance to the components of the product (see section ‘Composition’), pregnant and breastfeeding women, patients with bipolar psychosis, manic-depressive disorders and children. If you are taking antidepressants (in particular, selective serotonin reuptake inhibitors or tricyclics), monoamine oxidase inhibitors or tryptophan-containing agents, consult your doctor about the possibility of using Adonat®.
Consumption may cause gastrointestinal disorders. Dietary supplements should not be used as a substitute for a balanced diet. It is important to follow the rules of a varied, balanced diet and a healthy lifestyle. Do not exceed the recommended daily intake.

Form of release:
 10 tablets in a blister pack. 2 blister packs in a cardboard box.
Storage conditions:
Store in a dry and cool place, away from heat sources. The expiry date applies to a product whose blister pack has not been damaged and  which has been stored properly.
Keep out of reach of children.
Dietary supplement. Not a medicinal product.
Shelf life and batch number:
Indicated on the packaging and blister pack.
Name and location of the manufacturer:
Adonat® is a patented trademark of GNOSIS. The active ingredient ademetionine (SAMe) is manufactured in Switzerland by Gnosis Bioresearch S.A. 
Manufacturer's address: Via Lischedi, 4 6592 Sant'Antonino, Switzerland.
Tel +41.(0).91.851.91.91 
Tableting and packaging are carried out in Italy by FMC S.R.L. Manufacturer's address: Via Asi Consortile Km 0+200 03013 Ferentino (Fr) Italia. Tel (+39) 0775242054 | 07751831004.
Manufactured on behalf of VITASAIN SARL, Paris, France. Customer address: 52 Rue Saint-André des Arts 75006 Paris. Tel +33785904280.
Manufactured in accordance with GMP (Good Manufacturing Practice) standards, which guarantee that the product is manufactured and controlled in accordance with quality standards, in accordance with the trading licence, and is fit for its intended purpose.
Name and location of the market operator responsible for product information (handles consumer complaints):
VITASAN-UKRAINE LLC, legal address: 01042, Kyiv, Ukraine, 
Pecherskyi district, NOVOPECHERSKYI LANE, building 18, 
office 32. Tel +380673801918