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Instructions for use
Compound:
active ingredient: S-adenosyl-L-methionine (ademetionine, SAMe);
1 tablet contains 990 mg of S-adenosyl-L-methionine disulfate p-toluenesulfonate, which corresponds to 500 mg of ademetionine cation;
other components: film shell: shellac, acetic acid esters, mono- and diglycerides of fatty acids, polyvinylpyrrolidone; anti-caking agent: silicon dioxide, magnesium salts of fatty acids; filler: microcrystalline cellulose, magnesium hydroxide, sodium salt of carboxymethylcellulose.
Release form.
Enteric tablets.
Basic physical and chemical properties: film-coated tablets, oblong, white.
Properties.
S-adenosyl-L-methionine (ademetionine, SAM-e) is an amino acid present in almost all tissues and fluids of the body; it is the methylated form of methionine. Ademetionine primarily acts as a coenzyme and methyl group donor in transmethylation reactions, which is a necessary metabolic process in humans and animals. The transfer of methyl groups (transmethylation) is also a necessary metabolic process in the structure of the phospholipid bilayer in membrane cells and contributes to membrane fluidity. Ademetionine is able to penetrate the blood-brain barrier. The transmethylation process involving ademetionine is key in the formation of neurotransmitters of the central nervous system, including catecholamines (dopamine, norepinephrine, adrenaline), serotonin, melatonin and histamine.
Ademetionine is also a precursor in the formation of sulfurized physiological compounds (cysteine, taurine, glutathione, coenzyme A, etc.) in transsulfurization reactions. Glutathione, the most powerful antioxidant in the liver, plays an important nutrient in the processes of metabolism and restoration of ademetionine.
Recommended:
into the diet as a source of the amino acid ademetionine in order to compensate for the deficiency of endogenous S-adenosyl-L-methionine in the body, which can be observed in the following conditions:
• depression of various etiologies;
• intrahepatic cholestasis in adults with chronic hepatitis of various etiologies and liver cirrhosis;
• osteoarthrosis;
• chronic fatigue syndrome.
Apply:
1-2 tablets per day, washed down with a small amount of liquid. The tablets should be swallowed whole without chewing. Adonat tablets are coated with a special coating that dissolves only in the intestines. For better absorption of the active substance, tablets should be taken between meals.
Adonat tablets should be removed from the blister immediately before use.
The daily dosage of Adonat® and duration of administration are determined individually.
Warning. Do not take: in case of individual intolerance to the components of the product (see section “Composition”), pregnant women (the first six months of pregnancy), and women who are breastfeeding, patients with bipolar psychosis, children, with identified genetic defects affecting the methionine cycle and /or homocystinuria and/or hyperhomocysteinemia (for example, deficiency of cystathionine beta synthase, defect in vitamin B12 metabolism, patients with bipolar psychoses.
Because vitamin B12 and folic acid (folate) deficiencies can cause decreased ademetionine concentrations, patients at risk (anemia, liver disease, pregnancy, or the possibility of developing vitamin deficiency due to other diseases or dietary patterns such as veganism) should have regular blood tests to check plasma levels of these substances. If deficiency is found, treatment with vitamin B12 and/or folic acid (folates) is recommended before or during the use of ademetionine. If it is impossible to carry out these studies, patients at risk are recommended to use vitamin B12 and/or folic acid (folates) in dosages according to the doctor’s recommendations.
Ademetionine is also a precursor in the formation of sulfurized physiological compounds (cysteine, taurine, glutathione, coenzyme A, etc.) in transsulfurization reactions. Glutathione, the most powerful antioxidant in the liver, plays an important role in liver detoxification. Ademetionine increases the level of hepatic glutathione in patients with liver damage of both alcoholic and non-alcoholic origin.
Kidney failure. There are limited clinical data on the use of ademetionine in patients with renal failure. In such patients, ademetionine should be used after additional examinations by a doctor.
Ammonia levels should be monitored in patients with precirrhotic or cirrhotic hyperammonemia using ademetionine tablets.
Taking Adonat before bed, in particular at night, is undesirable, given the concomitant tonic effect of ademetionine.
When taking antidepressants (including selective serotonin reuptake inhibitors or tricyclics), monoamine oxidase inhibitors or drugs containing